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| NOZAKI, Hirofumi; ITONORI, Saki; SUGITA, Mutsumi; NAKAMURA, Kimihide; OHBA, Kiyoshi; OHNISHI, Masao; IMAI, Kunitoshi; IGARASHI, Yasuyuki; SUZUKI, Akemi; KUSHI, Yasunori; 中村, 公英; 大西, 正男; 今井, 邦俊. |
| https://www.jstage.jst.go.jp/article/bpb/33/4/33_4_580/_article |
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Palavras-chave: Alpha-galactosylceramide; Glycosphingolipid; Edible mushroom; Natural killer T cell; Mouse. |
| Ano: 2010 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3599 |
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| Tamaki, Yosui; Yoneda, Masashi; Sato, Keisuke; Yokohama, Shiro; Haneda, Masakazu; Nakamura, Kimihide; 中村, 公英. |
| The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20 mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con... |
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Palavras-chave: Concanavalin A; Tolerance; Cytokine; Liver injury; T cell. |
| Ano: 2006 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/61 |
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